Niacin requirements for genomic stability
JB Kirkland - … Research/Fundamental and Molecular Mechanisms of …, 2012 - Elsevier
Through its involvement in over 400 NAD (P)-dependent reactions, niacin status has the
potential to influence every area of metabolism. Niacin deficiency has been linked to
genomic instability largely through impaired function of the poly ADP-ribose polymerase
(PARP) family of enzymes. In various models, niacin deficiency has been found to cause
impaired cell cycle arrest and apoptosis, delayed DNA excision repair, accumulation of
single and double strand breaks, chromosomal breakage, telomere erosion and cancer …
potential to influence every area of metabolism. Niacin deficiency has been linked to
genomic instability largely through impaired function of the poly ADP-ribose polymerase
(PARP) family of enzymes. In various models, niacin deficiency has been found to cause
impaired cell cycle arrest and apoptosis, delayed DNA excision repair, accumulation of
single and double strand breaks, chromosomal breakage, telomere erosion and cancer …