[HTML][HTML] Use of the NADH-Quinone Oxidoreductase (NDI1) Gene ofSaccharomyces cerevisiae as a Possible Cure for Complex I Defects in Human Cells

BB Seo, JM Wang, TR Flotte, T Yagi… - Journal of Biological …, 2000 - ASBMB
The Ndi1 enzyme of Saccharomyces cerevisiae is a single subunit rotenone-insensitive
NADH-quinone oxidoreductase that is located on the matrix side of the inner mitochondrial
membrane. We have shown previously that theNDI1 gene can be functionally expressed in
Chinese hamster cells (Seo, BB, Kitajima-Ihara, T., Chan, EK, Scheffler, IE, Matsuno-Yagi,
A., and Yagi, T.(1998) Proc. Natl. Acad. Sci. USA 95, 9167–9171) and human embryonal
kidney 293 (HEK 293) cells (Seo, BB, Matsuno-Yagi, A., and Yagi, T.(1999) Biochim …