Hyperlipidemia is a major risk factor for developing atherosclerosis in humans, and
epidemiological studies have correlated specific lipoprotein levels with cardiovascular
disease risk. Murine models of atherosclerosis rely on the induction of hyperlipidemia for
vascular lesions to form, but the pathogenic contributions attributed to different lipoprotein
populations are not well defined. To address this issue, we analyzed over 300 LDL receptor
(LDLR) deficient mice that have been fed a high-fat diet and for which a full lipoprotein …