microRNAs (miRNAs) are small, non-coding RNAs with critical roles in fine-tuning a wide
array of biological processes including development, metabolism, and homeostasis.
miRNAs expression, similarly to that of protein-coding genes, is regulated by multiple
transcriptional networks as well as the epigenetic machinery. miRNA genes can be
epigenetically regulated by DNA methylation or specific histone modifications. In addition,
miRNAs can themselves repress key enzymes that drive epigenetic remodeling, generating …