Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis

YG Cho, ML Cho, SY Min, HY Kim - Autoimmunity reviews, 2007 - Elsevier
YG Cho, ML Cho, SY Min, HY Kim
Autoimmunity reviews, 2007Elsevier
Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship
between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long
time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied
extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA)
model has increased our understanding of the pathogenesis of human RA. In the present
report, we summarize the available information on anti-CII immunity and discuss recent …
Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.
Elsevier