The innate antiviral response is mediated, at least in part, by Toll-like receptors (TLRs).
TLR3 signaling is activated in response to viral infection, and the absence of TLR3 in mice
significantly increases mortality after infection with enteroviruses that cause myocarditis
and/or dilated cardiomyopathy. We screened TLR3 in patients diagnosed with enteroviral
myocarditis/cardiomyopathy and identified a rare variant in one patient as well as a
significantly increased occurrence of a common polymorphism compared with controls …