Myeloid-derived suppressor cells as regulators of the immune system

DI Gabrilovich, S Nagaraj - Nature reviews immunology, 2009 - nature.com
DI Gabrilovich, S Nagaraj
Nature reviews immunology, 2009nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to
suppress T-cell responses. These cells constitute a unique component of the immune
system that regulates immune responses in healthy individuals and in the context of various
diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive
functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.
Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.
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