Transforming growth factor β (TGFβ) superfamily polypeptides regulate cell growth and
differentiation by binding to single pass serine/threonine kinases referred to as TGFβ type I
and type II receptors. Signal propagation is dependent upon heteromeric (type I-type II)
complex formation and transphosphorylation of the type I receptor by the type II receptor.
While many of the phosphorylation events necessary for receptor signaling have recently
been characterized, the role of TGFβ receptor kinase activity in modulating receptor …