[HTML][HTML] IQGAP1-mediated stimulation of transcriptional co-activation by β-catenin is modulated by calmodulin
MW Briggs, Z Li, DB Sacks - Journal of Biological Chemistry, 2002 - ASBMB
β-Catenin, an oncoprotein integral to cell-cell adhesion and proliferative signaling, is
increased in several malignancies. The recently discovered calmodulin-binding protein
IQGAP1 binds stoichiometrically to β-catenin and regulates the association of β-catenin with
the cell-cell adhesion complex. In the present work, we investigated the role of IQGAP1 on
the transcriptional co-activator function of β-catenin, and whether calmodulin modulated the
functional interaction between IQGAP1 and β-catenin. In vitro competition assays revealed …
increased in several malignancies. The recently discovered calmodulin-binding protein
IQGAP1 binds stoichiometrically to β-catenin and regulates the association of β-catenin with
the cell-cell adhesion complex. In the present work, we investigated the role of IQGAP1 on
the transcriptional co-activator function of β-catenin, and whether calmodulin modulated the
functional interaction between IQGAP1 and β-catenin. In vitro competition assays revealed …