[HTML][HTML] SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells
N Nasrin, X Wu, E Fortier, Y Feng, OC Bare… - Journal of Biological …, 2010 - ASBMB
SIRT4, a member of the sirtuin family, has been implicated in the regulation of insulin
secretion by modulation of glutamate dehydrogenase. However, the role of this enzyme in
the regulation of metabolism in other tissues is unknown. In this study we investigated
whether depletion of SIRT4 would enhance liver and muscle metabolic functions. To do this
SIRT4 was knocked down using an adenoviral shRNA in mouse primary hepatocytes and
myotubes. We observed a significant increase in gene expression of mitochondrial and fatty …
secretion by modulation of glutamate dehydrogenase. However, the role of this enzyme in
the regulation of metabolism in other tissues is unknown. In this study we investigated
whether depletion of SIRT4 would enhance liver and muscle metabolic functions. To do this
SIRT4 was knocked down using an adenoviral shRNA in mouse primary hepatocytes and
myotubes. We observed a significant increase in gene expression of mitochondrial and fatty …