Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
TF Outeiro, E Kontopoulos, SM Altmann, I Kufareva… - science, 2007 - science.org
TF Outeiro, E Kontopoulos, SM Altmann, I Kufareva, KE Strathearn, AM Amore, CB Volk…
science, 2007•science.orgThe sirtuins are members of the histone deacetylase family of proteins that participate in a
variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin
2 (SIRT2) and found that inhibition of SIRT2 rescued α-synuclein toxicity and modified
inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2
via small interfering RNA similarly rescued α-synuclein toxicity. Furthermore, the inhibitors
protected against dopaminergic cell death both in vitro and in a Drosophila model of …
variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin
2 (SIRT2) and found that inhibition of SIRT2 rescued α-synuclein toxicity and modified
inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2
via small interfering RNA similarly rescued α-synuclein toxicity. Furthermore, the inhibitors
protected against dopaminergic cell death both in vitro and in a Drosophila model of …
The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued α-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.
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