Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

H Abe, N Yamada, K Kamata, T Kuwaki… - The Journal of …, 1998 - Am Soc Clin Investig
H Abe, N Yamada, K Kamata, T Kuwaki, M Shimada, J Osuga, F Shionoiri, N Yahagi
The Journal of clinical investigation, 1998Am Soc Clin Investig
Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity
and impaired glucose tolerance. This study examined the effects of insulin resistance on
coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance.
Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient
mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also
observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in …
Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions. Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance.
The Journal of Clinical Investigation