[PDF][PDF] Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

A Sparmann, D Bar-Sagi - Cancer cell, 2004 - cell.com
A Sparmann, D Bar-Sagi
Cancer cell, 2004cell.com
The role of Ras oncogenes in promoting cellular transformation is well established.
However, the contribution of Ras signaling to interactions between tumor cells and their host
environment remains poorly characterized. Here, we demonstrate that the inflammatory
mediator interleukin-8 (CXCL-8/IL-8) is a transcriptional target of Ras signaling. Using a
tumor xenograft model, we show that Ras-dependent CXCL-8 secretion is required for the
initiation of tumor-associated inflammation and neovascularization. Collectively, our data …
Abstract
The role of Ras oncogenes in promoting cellular transformation is well established. However, the contribution of Ras signaling to interactions between tumor cells and their host environment remains poorly characterized. Here, we demonstrate that the inflammatory mediator interleukin-8 (CXCL-8/IL-8) is a transcriptional target of Ras signaling. Using a tumor xenograft model, we show that Ras-dependent CXCL-8 secretion is required for the initiation of tumor-associated inflammation and neovascularization. Collectively, our data identify a novel mechanism by which the Ras oncogene can elicit a stromal response that fosters cancer progression.
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