Inflammatory networks in ageing, age-related diseases and longevity

S Vasto, G Candore, CR Balistreri, M Caruso… - Mechanisms of ageing …, 2007 - Elsevier
Inflammation is considered a response set by the tissues in response to injury elicited by
trauma or infection. It is a complex network of molecular and cellular interactions that
facilitates a return to physiological homeostasis and tissue repair. The individual response
against infection and trauma is also determined by gene variability. Ageing is accompanied
by chronic low-grade inflammation state clearly showed by 2–4-fold increase in serum levels
of inflammatory mediators. A wide range of factors has been claimed to contribute to this …