Accumulation of senescent cells in mitotic tissue of aging primates
JC Jeyapalan, M Ferreira, JM Sedivy… - Mechanisms of ageing and …, 2007 - Elsevier
Cellular senescence, a stress induced growth arrest of somatic cells, was first documented
in cell cultures over 40 years ago, however its physiological significance has only recently
been demonstrated. Using novel biomarkers of cellular senescence we examined whether
senescent cells accumulate in tissues from baboons of ages encompassing the entire
lifespan of this species. We show that dermal fibroblasts, displaying markers of senescence
such as telomere damage, active checkpoint kinase ATM, high levels of heterochromatin …
in cell cultures over 40 years ago, however its physiological significance has only recently
been demonstrated. Using novel biomarkers of cellular senescence we examined whether
senescent cells accumulate in tissues from baboons of ages encompassing the entire
lifespan of this species. We show that dermal fibroblasts, displaying markers of senescence
such as telomere damage, active checkpoint kinase ATM, high levels of heterochromatin …