Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors

G Voghel, N Thorin-Trescases, N Farhat… - Mechanisms of ageing …, 2007 - Elsevier
Risk factors for cardiovascular diseases (CVD) increase oxidative stress, and they are
proposed to hasten endothelial cell (EC) damage and dysfunction. Our objective was to
elucidate the impact of chronic exposure to risk factors for CVD on senescence of EC
isolated and cultured from internal mammary arterial segments of patients with severe
coronary artery disease. Senescence induced by serial passages resulted in progressive
telomere shortening, and short initial telomeres predicted early appearance of senescence …