Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming
C El Chartouni, L Schwarzfischer, M Rehli - Immunobiology, 2010 - Elsevier
Interleukin (IL)-4 is a central regulator of T helper 2 (Th2) immune responses, and also has a
major impact on innate immune cells. This cytokine primes macrophages for immune
responses to parasites and induces a distinct macrophage phenotype that may also promote
tissue repair. IL-4 signaling in macrophages is primarily mediated by the transcription factor
signal transducer and activator of transcription 6 (Stat6), which in turn regulates a number of
secondary DNA binding proteins that may participate in shaping the resulting phenotype …
major impact on innate immune cells. This cytokine primes macrophages for immune
responses to parasites and induces a distinct macrophage phenotype that may also promote
tissue repair. IL-4 signaling in macrophages is primarily mediated by the transcription factor
signal transducer and activator of transcription 6 (Stat6), which in turn regulates a number of
secondary DNA binding proteins that may participate in shaping the resulting phenotype …