Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

C Franceschi, M Capri, D Monti, S Giunta… - Mechanisms of ageing …, 2007 - Elsevier
A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low
grade chronic pro-inflammatory status we proposed to call inflammaging. Within this
perspective, healthy aging and longevity are likely the result not only of a lower propensity to
mount inflammatory responses but also of efficient anti-inflammatory networks, which in
normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong …