The ageing immune system: is it ever too old to become young again?

K Dorshkind, E Montecino-Rodriguez… - Nature Reviews …, 2009 - nature.com
K Dorshkind, E Montecino-Rodriguez, RAJ Signer
Nature Reviews Immunology, 2009nature.com
Ageing is accompanied by a decline in the function of the immune system, which increases
susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the
ageing immune system would therefore be beneficial for elderly individuals and would
decrease health-care costs for society. But is the immune system ever too old to become
young again? We review here the promise of various approaches to rejuvenate the function
of the immune system in the rapidly growing ageing population.
Abstract
Ageing is accompanied by a decline in the function of the immune system, which increases susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the ageing immune system would therefore be beneficial for elderly individuals and would decrease health-care costs for society. But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population.
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