B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

Z Keren, S Naor, S Nussbaum, K Golan… - Blood, The Journal …, 2011 - ashpublications.org
Z Keren, S Naor, S Nussbaum, K Golan, T Itkin, Y Sasaki, M Schmidt-Supprian, T Lapidot…
Blood, The Journal of the American Society of Hematology, 2011ashpublications.org
Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation
of long-lived B cells in the periphery. These changes decrease the body's ability to mount
protective antibody responses. We show here that age-related changes in the B lineage are
mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was
followed by expansion of multipotent primitive progenitors and common lymphoid
progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a …
Abstract
Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was followed by expansion of multipotent primitive progenitors and common lymphoid progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence.
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