[HTML][HTML] Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila …
WC Orr, RJ Mockett, JJ Benes, RS Sohal - Journal of Biological Chemistry, 2003 - ASBMB
The overexpression of antioxidative enzymes such as CuZn-superoxide dismutase (SOD),
Mn-SOD, and catalase has previously been reported to extend life span in transgenic flies
(Drosophila melanogaster). The purpose of this study was to determine whether life-
extending effects persist if the recipient control strains of flies are relatively long-lived.
Accordingly, the life spans of large numbers of replicate control and overexpressor lines
were determined in two long-lived genetic backgrounds involving a combined total of> …
Mn-SOD, and catalase has previously been reported to extend life span in transgenic flies
(Drosophila melanogaster). The purpose of this study was to determine whether life-
extending effects persist if the recipient control strains of flies are relatively long-lived.
Accordingly, the life spans of large numbers of replicate control and overexpressor lines
were determined in two long-lived genetic backgrounds involving a combined total of> …