Liver mitochondrial respiratory functions decline with age
TC Yen, YS Chen, KL King, SH Yeh, YH Wei - Biochemical and biophysical …, 1989 - Elsevier
TC Yen, YS Chen, KL King, SH Yeh, YH Wei
Biochemical and biophysical research communications, 1989•ElsevierHuman liver mitochondrial respiration rates in Chinese populations of various ages were
assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory
control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76
years old. We found a significant negative correlation between age and respiration rate with
all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the
increase of age. These findings suggest that a substantial fall in mitochondrial oxidative …
assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory
control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76
years old. We found a significant negative correlation between age and respiration rate with
all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the
increase of age. These findings suggest that a substantial fall in mitochondrial oxidative …
Abstract
Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiration rate with all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.
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