A morphometric study of age-dependent changes in mitochondrial populations of mouse liver and heart

GH Herbener - Journal of gerontology, 1976 - academic.oup.com
GH Herbener
Journal of gerontology, 1976academic.oup.com
Mitochondria in sections of liver and heart (wall of left ventricle) from C57BL/6J mice, 8, 30
and 43 to 44 mo. Old, were analyzed, using sterological techniques. The mitochondrial
volume density decreased with age jn both tissues: in liver the value estimated as 43 to
44mo. Of age was 65% the value estimated at 8-mo. of age; in the heart the 43 to 44 mo.
Value was 84% of the 8-mo. value. In both tissues, the decrease in mitochondrial volume
density was the result of a decrease in the mitochondrial numerical density: the average …
Abstract
Mitochondria in sections of liver and heart (wall of left ventricle) from C57BL/6J mice, 8, 30 and 43 to 44 mo. Old, were analyzed, using sterological techniques. The mitochondrial volume density decreased with age jn both tissues: in liver the value estimated as 43 to 44mo. Of age was 65% the value estimated at 8-mo. of age; in the heart the 43 to 44 mo. Value was 84% of the 8-mo. value. In both tissues, the decrease in mitochondrial volume density was the result of a decrease in the mitochondrial numerical density: the average volume of the mitochondrion remained constant throughout life.
Oxford University Press