The p53 tumour suppressor gene
AJ Levine, J Momand, CA Finlay - Nature, 1991 - nature.com
AJ Levine, J Momand, CA Finlay
Nature, 1991•nature.comThe cell cycle is composed of a series of steps which can be negatively or postively
regulated by various factors. Chief among the negative regulators is the p53 protein.
Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of
DNA tumour viruses, can lead to cancer. These mutations seem to be the most common
genetic change in human cancers.
regulated by various factors. Chief among the negative regulators is the p53 protein.
Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of
DNA tumour viruses, can lead to cancer. These mutations seem to be the most common
genetic change in human cancers.
Abstract
The cell cycle is composed of a series of steps which can be negatively or postively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. These mutations seem to be the most common genetic change in human cancers.
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