[HTML][HTML] The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene
SL Schissel, GA Keesler, EH Schuchman… - Journal of Biological …, 1998 - ASBMB
The acid sphingomyelinase (ASM) gene, which has been implicated in ceramide-mediated
cell signaling and atherogenesis, gives rise to both lysosomal SMase (L-SMase), which is
reportedly cation-independent, and secretory SMase (S-SMase), which is fully or partially
dependent on Zn 2+ for enzymatic activity. Herein we present evidence for a model to
explain how a single mRNA gives rise to two forms of SMase with different cellular trafficking
and apparent differences in Zn 2+ dependence. First, we show that both S-SMase and L …
cell signaling and atherogenesis, gives rise to both lysosomal SMase (L-SMase), which is
reportedly cation-independent, and secretory SMase (S-SMase), which is fully or partially
dependent on Zn 2+ for enzymatic activity. Herein we present evidence for a model to
explain how a single mRNA gives rise to two forms of SMase with different cellular trafficking
and apparent differences in Zn 2+ dependence. First, we show that both S-SMase and L …