Lifelong angiotensin-converting enzyme inhibition, pressure natriuresis, and renin-angiotensin system gene expression in transgenic (mRen-2) 27 rats.
A Lippoldt, V Gross, JU Bohlender… - Journal of the …, 1996 - journals.lww.com
The transgenic rat (TGR)(mRen-2) 27 is said to have low circulating active renin values in
plasma and little or no renin gene expression in the kidney. Nevertheless, intrarenal
angiotensin II-related effects appear to be responsible for the rightward shift in pressure-
natriuresis curves of TGR. To clarify the role of the intrarenal renin-angiotensin system in
modulating TGR pressure-natriuresis, TGR were given lifelong lisinopril by treating TGR and
their mothers before conception. Rat and mouse renin, AT1 receptor, and angiotensinogen …
plasma and little or no renin gene expression in the kidney. Nevertheless, intrarenal
angiotensin II-related effects appear to be responsible for the rightward shift in pressure-
natriuresis curves of TGR. To clarify the role of the intrarenal renin-angiotensin system in
modulating TGR pressure-natriuresis, TGR were given lifelong lisinopril by treating TGR and
their mothers before conception. Rat and mouse renin, AT1 receptor, and angiotensinogen …