Vascular calcification: in vitro evidence for the role of inorganic phosphate
CM Giachelli - Journal of the American Society of Nephrology, 2003 - journals.lww.com
Uremic patients are prone to widespread ectopic extraskeletal calcification resulting from an
imbalance of systemic inorganic phosphate (Pi). There can be serious consequences of this
process, particularly when it results in the calcification of the vasculature. A recent study
examined the response of cultured human aortic smooth muscle cells to varying levels of
extracellular Pi. Cells that were exposed to Pi levels similar to those seen in uremic patients
(> 1.4 mmol/L) showed dose-dependent increases in cell culture calcium deposition. The …
imbalance of systemic inorganic phosphate (Pi). There can be serious consequences of this
process, particularly when it results in the calcification of the vasculature. A recent study
examined the response of cultured human aortic smooth muscle cells to varying levels of
extracellular Pi. Cells that were exposed to Pi levels similar to those seen in uremic patients
(> 1.4 mmol/L) showed dose-dependent increases in cell culture calcium deposition. The …