[HTML][HTML] Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus
V Spindler, WM Heupel, A Efthymiadis… - Journal of Biological …, 2009 - ASBMB
Desmocollin (Dsc) 1–3 and desmoglein (Dsg) 1–4, transmembrane proteins of the cadherin
family, form the adhesive core of desmosomes. Here we provide evidence that Dsc3 homo-
and heterophilic trans-interaction is crucial for epidermal integrity. Single molecule atomic
force microscopy (AFM) revealed homophilic trans-interaction of Dsc3. Dsc3 displayed
heterophilic interaction with Dsg1 but not with Dsg3. A monoclonal antibody targeted against
the extracellular domain reduced homophilic and heterophilic binding as measured by AFM …
family, form the adhesive core of desmosomes. Here we provide evidence that Dsc3 homo-
and heterophilic trans-interaction is crucial for epidermal integrity. Single molecule atomic
force microscopy (AFM) revealed homophilic trans-interaction of Dsc3. Dsc3 displayed
heterophilic interaction with Dsg1 but not with Dsg3. A monoclonal antibody targeted against
the extracellular domain reduced homophilic and heterophilic binding as measured by AFM …