[HTML][HTML] Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3-and MTA1/Wnt1 protein-dependent …

D Yan, D Avtanski, NK Saxena, D Sharma - Journal of biological chemistry, 2012 - ASBMB
Perturbations in the adipocytokine profile, especially higher levels of leptin, are a major
cause of breast tumor progression and metastasis; the underlying mechanisms, however,
are not well understood. In particular, it remains elusive whether leptin is involved in
epithelial-mesenchymal transition (EMT). Here, we provide molecular evidence that leptin
induces breast cancer cells to undergo a transition from epithelial to spindle-like
mesenchymal morphology. Investigating the downstream mediator (s) that may direct leptin …