[HTML][HTML] Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
C Weigert, AM Hennige, R Lehmann… - Journal of Biological …, 2006 - ASBMB
The exercise-induced interleukin (IL)-6 production and secretion within skeletal muscle
fibers has raised the question of a putative tissue-specific function of IL-6 in the energy
metabolism of the muscle during and after the exercise. In the present study, we followed the
hypothesis that IL-6 signaling may directly interact with insulin receptor substrate (IRS)-1, a
keystone in the insulin signaling cascade. We showed that IL-6 induces a rapid recruitment
of IRS-1 to the IL-6 receptor complex in cultured skeletal muscle cells. Moreover, IL-6 …
fibers has raised the question of a putative tissue-specific function of IL-6 in the energy
metabolism of the muscle during and after the exercise. In the present study, we followed the
hypothesis that IL-6 signaling may directly interact with insulin receptor substrate (IRS)-1, a
keystone in the insulin signaling cascade. We showed that IL-6 induces a rapid recruitment
of IRS-1 to the IL-6 receptor complex in cultured skeletal muscle cells. Moreover, IL-6 …