Background Randomised trials have shown that aspirin reduces the short-term risk of
recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large
trials have shown no effect in primary prevention of colorectal cancer during 10 years' follow-
up. However, the delay from the early development of adenoma to presentation with cancer
is at least 10 years. We aimed to assess the longer-term effect of aspirin on the incidence of
cancers. Methods We studied the effect of aspirin in two large randomised trials with reliable …

British Doctors Aspirin Trial and the UK-TIA Aspirin Trial : Effect of aspirin on long-term risk of
colorectal cancer : consistent evidence from randomised and observational studies | CiNii
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