[HTML][HTML] Three subunit a isoforms of mouse vacuolar H+-ATPase: preferential expression of the a3 isoform during osteoclast differentiation
T Toyomura, T Oka, C Yamaguchi, Y Wada… - Journal of biological …, 2000 - ASBMB
Vacuolar H+-ATPase (V-ATPase) is a multi-subunit enzyme with a membrane peripheral
catalytic (V 1) and an intrinsic (V o) sector. We have identified three cDNA clones coding for
isoforms of mouse V o subunit a (a1, a2, and a3). They exhibit 48–52% identity with each
other and high similarity to subunit a of other species. Thea1 isoform was mainly expressed
in brain and liver. Thea2 isoform was observed in heart and kidney in addition to brain and
liver. Transcripts for the a3 isoform were strongly expressed in heart and liver. The a3 …
catalytic (V 1) and an intrinsic (V o) sector. We have identified three cDNA clones coding for
isoforms of mouse V o subunit a (a1, a2, and a3). They exhibit 48–52% identity with each
other and high similarity to subunit a of other species. Thea1 isoform was mainly expressed
in brain and liver. Thea2 isoform was observed in heart and kidney in addition to brain and
liver. Transcripts for the a3 isoform were strongly expressed in heart and liver. The a3 …