[HTML][HTML] Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression

HY Hsu, MH Wen - Journal of Biological Chemistry, 2002 - ASBMB
Lipopolysaccharide (LPS) stimulates macrophages to release inflammatory cytokines,
interleukin-1β (IL-1), and tumor necrosis factor (TNF). LPS-induced TNF suppresses
scavenger receptor functions in macrophages (van Lenten, BJ, and Fogelman, AM (1992) J.
Immunol. 148, 112–116), which is regulated by TNF-mediated protein kinases (Hsu, HY, and
Twu, YC (2000) J. Biol. Chem. 275, 41035–41048). To examine the molecular mechanism
for LPS induction of IL-1 in macrophages, we demonstrated that LPS quickly stimulated …