Treatment of cachexia with ghrelin in patients with COPD
N Nagaya, T Itoh, S Murakami, H Oya, M Uematsu… - Chest, 2005 - Elsevier
Study objectives Ghrelin is a novel growth hormone (GH)-releasing peptide that also
induces a positive energy balance by decreasing fat utility and stimulating feeding through
GH-independent mechanisms. We investigated whether ghrelin improves cachexia and
functional capacity in patients with COPD. Methods This is an open-label pilot study. Human
ghrelin (2 μg/kg bid) was IV administered to seven cachectic patients with COPD for 3
weeks. Food intake, body composition, muscle strength, exercise capacity, pulmonary …
induces a positive energy balance by decreasing fat utility and stimulating feeding through
GH-independent mechanisms. We investigated whether ghrelin improves cachexia and
functional capacity in patients with COPD. Methods This is an open-label pilot study. Human
ghrelin (2 μg/kg bid) was IV administered to seven cachectic patients with COPD for 3
weeks. Food intake, body composition, muscle strength, exercise capacity, pulmonary …