[HTML][HTML] GPVI and CLEC‐2 in hemostasis and vascular integrity
SP Watson, JMJ Herbert, AY Pollitt - Journal of Thrombosis and …, 2010 - Elsevier
Summary The glycoprotein VI (GPVI)–FcR γ‐chain complex initiates powerful activation of
platelets by the subendothelial matrix proteins collagen and laminin through an
immunoreceptor tyrosine‐based activation motif (ITAM)‐regulated signaling pathway. ITAMs
are characterized by two YxxL sequences separated by 6–12 amino acids and are found
associated with several classes of immunoglobulin (Ig) and C‐type lectin receptors in
hematopoietic cells, including Fc receptors. Cross‐linking of the Ig GPVI leads to …
platelets by the subendothelial matrix proteins collagen and laminin through an
immunoreceptor tyrosine‐based activation motif (ITAM)‐regulated signaling pathway. ITAMs
are characterized by two YxxL sequences separated by 6–12 amino acids and are found
associated with several classes of immunoglobulin (Ig) and C‐type lectin receptors in
hematopoietic cells, including Fc receptors. Cross‐linking of the Ig GPVI leads to …