Platelet-neutrophil-interactions: linking hemostasis and inflammation

A Zarbock, RK Polanowska-Grabowska, K Ley - Blood reviews, 2007 - Elsevier
Platelets are essential for primary hemostasis, but they also play an important pro-
inflammatory role. Platelets normally circulate in a quiescent state. Upon activation, platelets
can secrete and present various molecules, change their shape as well as the expression
pattern of adhesion molecules. These changes are associated with the adhesion of platelets
to leukocytes and the vessel wall. The interaction of platelets with neutrophils promotes the
recruitment of neutrophils into inflammatory tissue and thus participates in host defense. This …