Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer
MM Goldenberg - Clinical therapeutics, 1999 - Elsevier
Amplification of the human epidermal growth factor receptor 2 protein (HER2) in primary
breast carcinomas has been shown to correlate with poor clinical prognosis for certain
patients. Trastuzumab (Herceptin®, Genentech, Inc., South San Francisco, California) is a
highly purified recombinant DNA-derived humanized monoclonal immunoglobulin G1 kappa
antibody that binds with high affinity and specificity to the extracellular domain of the HER2
receptor. In vitro and in vivo preclinical studies have shown that administration of …
breast carcinomas has been shown to correlate with poor clinical prognosis for certain
patients. Trastuzumab (Herceptin®, Genentech, Inc., South San Francisco, California) is a
highly purified recombinant DNA-derived humanized monoclonal immunoglobulin G1 kappa
antibody that binds with high affinity and specificity to the extracellular domain of the HER2
receptor. In vitro and in vivo preclinical studies have shown that administration of …