A receptor for green tea polyphenol EGCG
H Tachibana, K Koga, Y Fujimura… - Nature structural & …, 2004 - nature.com
Nature structural & molecular biology, 2004•nature.com
The major polyphenol in green tea,(−)-epigallocatechin-3-gallate (EGCG), has been shown
to prevent carcinogenesis. We have identified a receptor that mediates the anticancer
activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers
EGCG responsiveness to cancer cells at physiologically relevant concentrations.
Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa
laminin receptor with a nanomolar K d value.
to prevent carcinogenesis. We have identified a receptor that mediates the anticancer
activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers
EGCG responsiveness to cancer cells at physiologically relevant concentrations.
Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa
laminin receptor with a nanomolar K d value.
Abstract
The major polyphenol in green tea, (−)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar Kd value.
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