The evidence-based use of thiazide diuretics in hypertension and nephrolithiasis
RF Reilly, AJ Peixoto, GV Desir - Clinical Journal of the American …, 2010 - journals.lww.com
Thiazide-type diuretics are commonly used in the treatment of hypertension and
nephrolithiasis. Evidence from randomized clinical trials needs to be considered in
decisions about agent choice and dose. In nephrolithiasis, one of the major limitations of the
literature is a paucity of data on the dose-response effect of hydrochlorothiazide (HCTZ) on
urinary calcium excretion. The best available evidence for prevention of stone recurrence
suggests the use of indapamide at 2.5 mg/d, chlorthalidone at 25 to 50 mg daily, or HCTZ 25 …
nephrolithiasis. Evidence from randomized clinical trials needs to be considered in
decisions about agent choice and dose. In nephrolithiasis, one of the major limitations of the
literature is a paucity of data on the dose-response effect of hydrochlorothiazide (HCTZ) on
urinary calcium excretion. The best available evidence for prevention of stone recurrence
suggests the use of indapamide at 2.5 mg/d, chlorthalidone at 25 to 50 mg daily, or HCTZ 25 …