The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

J Hardy, DJ Selkoe - science, 2002 - science.org
science, 2002science.org
It has been more than 10 years since it was first proposed that the neurodegeneration in
Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques
in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the
primary influence driving AD pathogenesis. The rest of the disease process, including
formation of neurofibrillary tangles containing tau protein, is proposed to result from an
imbalance between Aβ production and Aβ clearance.
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance.
AAAS