Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
E Alberdi, MV Sánchez-Gómez, F Cavaliere… - Cell calcium, 2010 - Elsevier
Amyloid beta (Aβ) oligomers accumulate in brain tissue of Alzheimer disease patients and
are related to pathogenesis. The precise mechanisms by which Aβ oligomers cause
neurotoxicity remain unresolved. In this study, we investigated the role of ionotropic
glutamate receptors on the intracellular Ca2+ overload caused by Aβ. Using rat cortical
neurons in culture and entorhinal–hippocampal organotypic slices, we found that Aβ
oligomers significantly induced inward currents, intracellular Ca2+ increases and apoptotic …
are related to pathogenesis. The precise mechanisms by which Aβ oligomers cause
neurotoxicity remain unresolved. In this study, we investigated the role of ionotropic
glutamate receptors on the intracellular Ca2+ overload caused by Aβ. Using rat cortical
neurons in culture and entorhinal–hippocampal organotypic slices, we found that Aβ
oligomers significantly induced inward currents, intracellular Ca2+ increases and apoptotic …