[PDF][PDF] Brain insulin controls adipose tissue lipolysis and lipogenesis

T Scherer, J O'Hare, K Diggs-Andrews, M Schweiger… - Cell metabolism, 2011 - cell.com
T Scherer, J O'Hare, K Diggs-Andrews, M Schweiger, B Cheng, C Lindtner, E Zielinski…
Cell metabolism, 2011cell.com
White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2
diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading
to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases
the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that
insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases
WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and …
Summary
White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.
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