The development of androgen-independent prostate cancer
BJ Feldman, D Feldman - Nature Reviews Cancer, 2001 - nature.com
BJ Feldman, D Feldman
Nature Reviews Cancer, 2001•nature.comThe normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured
by surgery eventually become androgen independent, rendering anti-androgen therapy
ineffective. But how does androgen independence arise? We predict that understanding the
pathways that lead to the development of androgen-independent prostate cancer will pave
the way to effective therapies for these, at present, untreatable cancers.
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured
by surgery eventually become androgen independent, rendering anti-androgen therapy
ineffective. But how does androgen independence arise? We predict that understanding the
pathways that lead to the development of androgen-independent prostate cancer will pave
the way to effective therapies for these, at present, untreatable cancers.
Abstract
The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen independent, rendering anti-androgen therapy ineffective. But how does androgen independence arise? We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers.
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