Bicalutamide (Casodex)-induced prostate regression involves increased expression of genes encoding insulin-like growth factor binding proteins
T Nickerson, M Pollak - Urology, 1999 - Elsevier
Objectives. To examine the effects of bicalutamide (Casodex), a pure antiandrogen with high
specificity for the androgen receptor, on insulin-like growth factor binding protein (IGFBP)
expression and apoptotic regression of the rat ventral prostate. Methods. Rats were treated
daily with 10 mg/kg body weight bicalutamide or vehicle alone. Ventral prostates were
collected at various days of treatment. Northern blot analysis was performed to quantitate
expression of genes encoding IGFBPs, and the TUNEL method was used to determine the …
specificity for the androgen receptor, on insulin-like growth factor binding protein (IGFBP)
expression and apoptotic regression of the rat ventral prostate. Methods. Rats were treated
daily with 10 mg/kg body weight bicalutamide or vehicle alone. Ventral prostates were
collected at various days of treatment. Northern blot analysis was performed to quantitate
expression of genes encoding IGFBPs, and the TUNEL method was used to determine the …