[HTML][HTML] Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K …
Skeletal muscle size is regulated by anabolic (hypertrophic) and catabolic (atrophic)
processes. We first characterized molecular markers of both hypertrophy and atrophy and
identified a small subset of genes that are inversely regulated in these two settings (eg up-
regulated by an inducer of hypertrophy, insulin-like growth factor-1 (IGF-1), and down-
regulated by a mediator of atrophy, dexamethasone). The genes identified as being
inversely regulated by atrophy, as opposed to hypertrophy, include the E3 ubiquitin ligase …
processes. We first characterized molecular markers of both hypertrophy and atrophy and
identified a small subset of genes that are inversely regulated in these two settings (eg up-
regulated by an inducer of hypertrophy, insulin-like growth factor-1 (IGF-1), and down-
regulated by a mediator of atrophy, dexamethasone). The genes identified as being
inversely regulated by atrophy, as opposed to hypertrophy, include the E3 ubiquitin ligase …