Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer
Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-
related EOC was associated with an improved prognosis, but the effect of BRCA1 remains
unclear. Objective To characterize the survival of BRCA carriers with EOC compared with
noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival
patterns. Design, Setting, and Participants A pooled analysis of 26 observational studies on …
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-
related EOC was associated with an improved prognosis, but the effect of BRCA1 remains
unclear. Objective To characterize the survival of BRCA carriers with EOC compared with
noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival
patterns. Design, Setting, and Participants A pooled analysis of 26 observational studies on …