A function for the macrophage F4/80 molecule in tolerance induction

TK van den Berg, G Kraal - Trends in immunology, 2005 - cell.com
Trends in immunology, 2005cell.com
The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages.
The antigen (Ag) recognized by the antibody has been characterized as a member of the
epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the
molecule has remained elusive. A recent study provides evidence for a role of the F4/80
molecule in the induction of immunological tolerance. This study appears to provide clear
evidence for a role of the F4/80 molecule in the immune system, however, what does it really …
The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?
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