[HTML][HTML] Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial …

WX Ding, HM Ni, M Li, Y Liao, X Chen, DB Stolz… - Journal of Biological …, 2010 - ASBMB
Damaged mitochondria can be eliminated by autophagy, ie mitophagy, which is important
for cellular homeostasis and cell survival. Despite the fact that a number of factors have
been found to be important for mitophagy in mammalian cells, their individual roles in the
process had not been clearly defined. Parkin is a ubiquitin-protein isopeptide ligase able to
translocate to the mitochondria that are to be removed. We showed here in a chemical
hypoxia model of mitophagy induced by an uncoupler, carbonyl cyanide m …