[HTML][HTML] XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy
Y Liu, J Zhou, W Zhao, X Li, R Jiang, C Liu… - Journal of Biological …, 2012 - ASBMB
BMP2 (bone morphogenetic protein 2) is known to activate unfolded protein response
signaling molecules, including XBP1S and ATF6. However, the influence on XBP1S and
ATF6 in BMP2-induced chondrocyte differentiation has not yet been elucidated. In this study,
we demonstrate that BMP2 mediates mild endoplasmic reticulum stress-activated ATF6 and
directly regulates XBP1S splicing in the course of chondrogenesis. XBP1S is differentially
expressed during BMP2-stimulated chondrocyte differentiation and exhibits prominent …
signaling molecules, including XBP1S and ATF6. However, the influence on XBP1S and
ATF6 in BMP2-induced chondrocyte differentiation has not yet been elucidated. In this study,
we demonstrate that BMP2 mediates mild endoplasmic reticulum stress-activated ATF6 and
directly regulates XBP1S splicing in the course of chondrogenesis. XBP1S is differentially
expressed during BMP2-stimulated chondrocyte differentiation and exhibits prominent …