[HTML][HTML] Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1
H Okuyama, B Krishnamachary, YF Zhou… - Journal of Biological …, 2006 - ASBMB
Bone marrow-derived cells are recruited to sites of ischemia, where they promote tissue
vascularization. This response is dependent upon the expression of vascular endothelial
growth factor (VEGF) receptor 1 (VEGFR1), which mediates cell migration in response to
VEGF or placental growth factor (PLGF). In this study, we found that exposure of cultured
mouse bone marrow-derived mesenchymal stromal cells (MSC) to hypoxia or an adenovirus
encoding a constitutively active form of hypoxia-inducible factor 1 (HIF-1) induced VEGFR1 …
vascularization. This response is dependent upon the expression of vascular endothelial
growth factor (VEGF) receptor 1 (VEGFR1), which mediates cell migration in response to
VEGF or placental growth factor (PLGF). In this study, we found that exposure of cultured
mouse bone marrow-derived mesenchymal stromal cells (MSC) to hypoxia or an adenovirus
encoding a constitutively active form of hypoxia-inducible factor 1 (HIF-1) induced VEGFR1 …